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According to the research literature, about three quarters of the men who got alarming PSA scores and were subjected to the discomfort and infection risk of a prostate biopsy turned out to be false positives no cancer found. And the men whose biopsies came back with cancer, for whom PSA had done its job of early detection, were in a quandary. “Roughly half the elderly men in America have evidence of cancer in their prostate, yet only 3 percent will die from it,” Welch says.

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